The Potential of Snail Seromucous and Chitosan as Bioimunomodulator for Tuberculosis Therapy

Tuberculosis (TB) as a global emergency is chronic disease caused by Mycobacterium tuberculosis (Mtb). Mtb plays an important role in inducing or suppressing the production of Interferon Gamma (IFNG) and IL-4 regulation TB homeostasis pathogenesis. The bioactive compounds snail seromucous (Achatina fulica Ferussac) chitosan function biological response modifiers. study aimed to determine potential effectiveness bio-immunomodulator for therapy. research method was based on results laboratory experiments with physic-chemical, biochemical, microbiological examination, protein profile, lymphocyte proliferation, measurement IFNG, levels. physic-chemical examination showed specific gravity 1.010; pH 8, glucose 16 mg/dL; cholesterol 9 2.8 mg/dL heavy metals (Pb, Cu, Hg, Al) negative. tests that 100% concentration antimicrobial against Staphylococcus aureus, Candida albicans, Pseudomonas aeruginosa. profile shows there are 3 subunits, namely range 55 - 72 kDa 1 sub-unit 43 compound achasin sulfate. Addition dose 65 µg/mL; µg/mL mixture (65 µg/mL): µg/mL) ratio 1: 1, can increase proliferation; optimum levels IFN-γ IL-4. Snail effective immunomodulators candidates